The synthesis of novel ultrafiltration membranes from chicken eggs shell waste was addressed. The novel CHES-UF membranes is designed and developed by IMTL@USIM. From highly abundant chicken eggs shell bio-waste, a special bio-active compounds was synthesized via a wet/dry chemical method. With an excellent properties, a special polymeric formulation was prepared. In bridging a new concept of active materials science involving of polymer and CHES, a unique characteristic of active skin response was created on the skin of CHES membranes. The designing of smooth, even and ultrathin active skin produced via phase inversion process made the CHES membranes to be versatile in the form of wide separation spectrum and operations. In addition, the novel CHES membranes having a uniform and narrow ‘on & in’ pores and able to promote high flux and selectivity. As the fabrication of CHES membranes is highly complicated and challenging, a fully controlled fabrication process (to be patented) enable the production of finer pores, pore statistics and pores types as well as defect-free structures towards a greener and economic process. Moreover, with excellent combinations of fine performance-properties-pores specifications, this project is crucial and in line with the government policies and industrial demands especially due to cost effective and towards minimizing the utilization of bio-waste as a valuable product and advance technology applications. Significantly, the CHES membranes was found to be highly potential for high impact industries such as biotechnology, wastewater treatment, biomedical, nutraceutical and food industry.